Characterization of a Spontaneous Retinal Neovascular Mouse Model

201438 citationsJournal Articlegold Open Access

Authors

Eiichi Hasegawa · Harvard University

Harry Sweigard · Massachusetts Eye and Ear Infirmary

Deeba Husain · Massachusetts Eye and Ear Infirmary

Ana María Olivares · Massachusetts Eye and Ear Infirmary

Bo Chang · Jackson Laboratory

Kaylee E. Smith · Massachusetts Eye and Ear Infirmary

Amy E. Birsner

Abstract

The NRV2 mouse strain develops early neovascular lesions within the retina, which grow downward towards the RPE beginning at p15. This retinal neovascularization model mimics early stages of human retinal angiomatous proliferation (RAP) and will likely be a useful in elucidating targeted therapeutics for patients with ocular neovascular disease.

Topics & Keywords

Retinal Diseases and Treatments Retinal Development and Disorders Retinal Imaging and Analysis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 9, Issue 9, pp. e106507-e106507

DOI: 10.1371/journal.pone.0106507

Field-Weighted Citation Impact: 1.99