Efficient, mild and completely regioselective synthesis of substituted pyridines

201061 citationsJournal Article

Authors

Thomas Sainte‐Luce Banchelin · Umeå University

Abstract

Addition of Grignard reagents to pyridine N-oxides in THF at low temperature (-78 to -20 degrees C) and treatment with TFAA provides an efficient general procedure for synthesis of substituted pyridines. The method is compatible with a range of functional groups such as esters, halogens and nitriles.

Topics & Keywords

Coordination Chemistry and Organometallics Synthesis of heterocyclic compounds Synthesis and Reactivity of Heterocycles

UN Sustainable Development Goals

Clean water and sanitation

Publication Details

Published in: Chemical Communications

Volume 46, Issue 19, pp. 3384-3384

DOI: 10.1039/c000748j

Field-Weighted Citation Impact: 3.30