MicroRNA Biogenesis Is Required for Mouse Primordial Germ Cell Development and Spermatogenesis

2008496 citationsJournal Articlegold Open Access

Authors

Katsuhiko Hayashi · Wellcome/Cancer Research UK Gurdon Institute

Susana M. Chuva de Sousa Lopes · Wellcome Trust

Masahiro Kaneda · Wellcome Trust

Fuchou Tang · Wellcome Trust

Petra Hájková · Wellcome/Cancer Research UK Gurdon Institute

Kaiqin Lao

Dónal O’Carroll · Rockefeller University

Abstract

These results illustrate that miRNAs are important for the proliferation of PGCs and spermatogonia, but dispensable for the repression of retrotransposons in developing germ cells. Consistently, miRNAs promoting cell cycling are highly expressed in PGCs and spermatogonia. Furthermore, based on normal spermatogenesis in Argonaute2-deficient testis, the critical function of Dicer in spermatogenesis is independent of Argonaute2.

Topics & Keywords

Chromosomal and Genetic Variations MicroRNA in disease regulation RNA Interference and Gene Delivery

UN Sustainable Development Goals

No poverty

Publication Details

Published in: PLoS ONE

Volume 3, Issue 3, pp. e1738-e1738

DOI: 10.1371/journal.pone.0001738

Field-Weighted Citation Impact: 45.55