RANTES Deposition by Platelets Triggers Monocyte Arrest on Inflamed and Atherosclerotic Endothelium

2001575 citationsJournal Article

Authors

Philipp von Hundelshausen · University of Virginia

Kim S. C. Weber · University of Virginia

Yuqing Huo · University of Virginia

Amanda E. I. Proudfoot · Merck (Germany)

Peter J. Nelson · Merck (Germany)

Klaus Ley · University of Virginia

Christian Weber

Abstract

The deposition of RANTES by platelets triggers shear-resistant monocyte arrest on inflamed or atherosclerotic endothelium. Delivery of RANTES by platelets may epitomize a novel principle relevant to inflammatory or atherogenic monocyte recruitment from the circulation.

Topics & Keywords

Cell Adhesion Molecules Research Atherosclerosis and Cardiovascular Diseases Platelet Disorders and Treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 103, Issue 13, pp. 1772-1777

DOI: 10.1161/01.cir.103.13.1772

Field-Weighted Citation Impact: 7.67