Aneuploidy and Confined Chromosomal Mosaicism in the Developing Human Brain

2007225 citationsJournal Articlegold Open Access

Authors

Yuri B. Yurov · Federal Agency for Health and Social Development

Ivan Y. Iourov · Federal Agency for Health and Social Development

Svetlana G. Vorsanova · Federal Agency for Health and Social Development

Thomas Liehr · Max Planck Institute for the Science of Human History

Alexei D. Kolotii · Federal Agency for Health and Social Development

Sergey I. Kutsev · Rostov State Medical University

Abstract

Our data indicates aneuploidization to be an additional pathological mechanism for neuronal genome diversification. These findings highlight the involvement of aneuploidy in the human brain development and suggest an unexpected link between developmental chromosomal instability, intercellural/intertissular genome diversity and human brain diseases.

Topics & Keywords

Genomic variations and chromosomal abnormalities Prenatal Screening and Diagnostics Chromatin Remodeling and Cancer

UN Sustainable Development Goals

Partnerships for the goals

Publication Details

Published in: PLoS ONE

Volume 2, Issue 6, pp. e558-e558

DOI: 10.1371/journal.pone.0000558

Field-Weighted Citation Impact: 7.79