Stimulation of Fecal Steroid Excretion After Infusion of Recombinant Proapolipoprotein A-I

1999232 citationsJournal Article

Authors

Mats Eriksson · Karolinska University Hospital

Lars A. Carlson · Karolinska University Hospital

Tatu A. Miettinen · Karolinska University Hospital

Bo Angelin · Karolinska University Hospital

Abstract

Infusion of proapoA-I liposomes in humans promotes net cholesterol excretion from the body, implying a stimulation of reverse cholesterol transport. This mechanism may prove useful in the treatment of atherosclerosis.

Topics & Keywords

Cholesterol and Lipid Metabolism Drug Transport and Resistance Mechanisms Diabetes, Cardiovascular Risks, and Lipoproteins

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 100, Issue 6, pp. 594-598

DOI: 10.1161/01.cir.100.6.594

Field-Weighted Citation Impact: 9.56