Emerging role of autophagy in kidney function, diseases and aging

2012249 citationsReviewbronze Open Access

Authors

Tobias B. Huber · University Medical Center Freiburg

Charles L. Edelstein · University of Colorado Denver

Björn Hartleben · University Medical Center Freiburg

Ken Inoki · Ann Arbor Center for Independent Living

Man Jiang · Charlie Norwood VA Medical Center

Daisuke Koya · Kanazawa Medical University

Shinji Kume

Abstract

Autophagy is a highly conserved process that degrades cellular long-lived proteins and organelles. Accumulating evidence indicates that autophagy plays a critical role in kidney maintenance, diseases and aging. Ischemic, toxic, immunological, and oxidative insults can cause an induction of autophagy in renal epithelial cells modifying the course of various kidney diseases. This review summarizes recent insights on the role of autophagy in kidney physiology and diseases alluding to possible novel intervention strategies for treating specific kidney disorders by modifying autophagy.

Topics & Keywords

Autophagy in Disease and Therapy Dialysis and Renal Disease Management Cannabis and Cannabinoid Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Autophagy

Volume 8, Issue 7, pp. 1009-1031

DOI: 10.4161/auto.19821

Field-Weighted Citation Impact: 12.32