The Transcription Factor PU.1 Regulates γδ T Cell Homeostasis

201110 citationsJournal Articlegold Open Access

Authors

Rukhsana Jabeen · Indiana University – Purdue University Indianapolis

Hua‐Chen Chang · Indiana University – Purdue University Indianapolis

Ritobrata Goswami · Indiana University – Purdue University Indianapolis

Stephen L. Nutt · Walter and Eliza Hall Institute of Medical Research

Mark H. Kaplan · Indiana University – Purdue University Indianapolis

Abstract

The increase of γδ T cell numbers in Lck-Cre deleter strains, where deletion occurs after PU.1 expression is diminished, as well as the observation that PU.1-deficient γδ T cells have greater proliferative responses than wild type cells, suggests that PU.1 effects are not developmental but rather at the level of homeostasis. Thus, our data shows that PU.1 has a negative influence on γδ T cell expansion.

Topics & Keywords

T-cell and B-cell Immunology Immune Cell Function and Interaction Immunotherapy and Immune Responses

Publication Details

Published in: PLoS ONE

Volume 6, Issue 7, pp. e22189-e22189

DOI: 10.1371/journal.pone.0022189

Field-Weighted Citation Impact: 0.62

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The Transcription Factor PU.1 Regulates γδ T Cell Homeostasis

Authors

Abstract

Topics & Keywords

Publication Details