Paclitaxel Stent Coating Inhibits Neointimal Hyperplasia at 4 Weeks in a Porcine Model of Coronary Restenosis

2001438 citationsJournal Article

Authors

Alan W. Heldman · Johns Hopkins University

Linda Cheng · Johns Hopkins University

G. Mark Jenkins · Johns Hopkins University

Phillip F. Heller · Johns Hopkins University

Dong Woon Kim · Johns Hopkins University

Melvin Ware · Johns Hopkins University

Cynthia Nater ·

Abstract

Paclitaxel-coated coronary stents produced a significant dose-dependent inhibition of neointimal hyperplasia and luminal encroachment in the pig LAD 28 days after implantation; later effects require further study. These results demonstrate the potential therapeutic benefit of paclitaxel-coated coronary stents in the prevention and treatment of human coronary restenosis.

Topics & Keywords

Coronary Interventions and Diagnostics Antiplatelet Therapy and Cardiovascular Diseases Cerebrovascular and Carotid Artery Diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 103, Issue 18, pp. 2289-2295

DOI: 10.1161/01.cir.103.18.2289

Field-Weighted Citation Impact: 31.51