Epithelial-Mesenchymal Transition in Cervical Cancer: Correlation with Tumor Progression, Epidermal Growth Factor Receptor Overexpression, and Snail Up-Regulation

2008257 citationsJournal Articlebronze Open Access

Authors

Mei-Yi Lee · Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences

Cheng-Yang Chou · Beijing Obstetrics and Gynecology Hospital

Meng‐Ru Shen · Beijing Obstetrics and Gynecology Hospital

Abstract

EGF cooperates with alpha(5)beta(1) integrin signaling to induce EMT in cervical cancer cells via up-regulated Snail. Blockade of EGFR activity or expression may provide a potential target for the treatment of cervical cancer progression.

Topics & Keywords

Cancer Cells and Metastasis Wnt/β-catenin signaling in development and cancer Cell Adhesion Molecules Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 14, Issue 15, pp. 4743-4750

DOI: 10.1158/1078-0432.ccr-08-0234

Field-Weighted Citation Impact: 5.04