Identification of novel functional organic anion-transporting polypeptide 1B3 polymorphisms and assessment of substrate specificity

201189 citationsJournal Article

Authors

Ute I. Schwarz · Western University

Henriette E. Meyer zu Schwabedissen · Western University

Rommel G. Tirona · Western University

Atsuko Suzuki · National Institute of Biomedical Innovation, Health and Nutrition

Brenda F. Leake · Vanderbilt University

Younes Mokrab · University of Cambridge

Kenji Mizuguchi

Abstract

OATP1B3 polymorphisms that result in altered expression, substrate specificity, and pH-dependent activity may be of potential relevance to hepatic clearance of substrate drugs in vivo.

Topics & Keywords

Drug Transport and Resistance Mechanisms Trace Elements in Health HIV/AIDS drug development and treatment

Publication Details

Published in: Pharmacogenetics and Genomics

Volume 21, Issue 3, pp. 103-114

DOI: 10.1097/fpc.0b013e328342f5b1

Field-Weighted Citation Impact: 3.99

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Identification of novel functional organic anion-transporting polypeptide 1B3 polymorphisms and assessment of substrate specificity

Authors

Abstract

Topics & Keywords

Publication Details