Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS‐4 and ADAMTS‐5

2007401 citationsJournal Article

Authors

Ruo-Hua Song

Micky D. Tortorella

David W. Griggs · Pfizer (United States)

Abstract

Despite the apparent dominant role of ADAMTS-5 in genetically modified mice, our data suggest that both ADAMTS-4 and ADAMTS-5 contribute to the structural damage that characterizes human OA.

Topics & Keywords

Osteoarthritis Treatment and Mechanisms Cell Adhesion Molecules Research Knee injuries and reconstruction techniques

Publication Details

Published in: Arthritis & Rheumatism

Volume 56, Issue 2, pp. 575-585

DOI: 10.1002/art.22334

Field-Weighted Citation Impact: 17.46

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Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS‐4 and ADAMTS‐5

Authors

Abstract

Topics & Keywords

Publication Details