NOTCH1, NOTCH3, NOTCH4, and JAG2 protein levels in human endometrial cancer

201437 citationsJournal Articlegold Open Access

Authors

Aušra Sasnauskienė

Violeta Jonušienė · Vilnius University

Aurelija Krikštaponienė · Vilnius University

Stasė Butkytė

Daiva Dabkevičienė · Vilnius University

Daiva Kanopienė · Vilnius University

Birutė Kazbarienė · Vilnius University

Janina Didžiapetrienė

Abstract

The reduced amount of NOTCH4 and JAG2 proteins and the decreased level of mRNA coding Notch proteins, as reported in our previous studies, supports the notion that Notch pathway has rather tumor-suppressive than oncogenic role in human endometrial cancer cells. It suggests that Notch pathway activation is a potential therapeutic target.

Topics & Keywords

Developmental Biology and Gene Regulation Cancer-related molecular mechanisms research Genetic factors in colorectal cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Medicina

Volume 50, Issue 1, pp. 14-18

DOI: 10.1016/j.medici.2014.05.002

Field-Weighted Citation Impact: 0.98