Granulocyte–Macrophage Progenitors as Candidate Leukemic Stem Cells in Blast-Crisis CML

20041,488 citationsJournal Articlebronze Open Access

Authors

Catriona Jamieson

Laurie Ailles

Armand Keating · University of Toronto

Charles L. Sawyers · University of California, Los Angeles

Abstract

Activation of beta-catenin in CML granulocyte-macrophage progenitors appears to enhance the self-renewal activity and leukemic potential of these cells.

Topics & Keywords

Chronic Myeloid Leukemia Treatments Eosinophilic Disorders and Syndromes Acute Lymphoblastic Leukemia research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 351, Issue 7, pp. 657-667

DOI: 10.1056/nejmoa040258

Field-Weighted Citation Impact: 41.01