Association of the Functional Polymorphism C677T in the Methylenetetrahydrofolate Reductase Gene with Colorectal, Thyroid, Breast, Ovarian, and Cervical Cancers

Our data taken together with other reports indicates that the polymorphism C677T of MTHFR is a risk factor for developing colorectal cancer but not cervical, thyroid, and breast cancers. The present study also reconfirms that frequencies of the variants are not gender-specific.