Local Simvastatin Effects on Mandibular Bone Growth and Inflammation

2005180 citationsJournal Articlegreen Open Access

Authors

David E. Stein · Surgical Specialties (United States)

Yeon‐Ju Lee · University of Nebraska Medical Center

Marian J. Schmid · University of Nebraska Medical Center

Byron Killpack · University of Nebraska Medical Center

Mikala A. Genrich · University of Nebraska Medical Center

Nagamani Narayana

Diane M. Cullen · Creighton University

Abstract

Reducing the simvastatin dose from 2.2 to 0.5 mg reduced inflammation to a more clinically acceptable level without sacrificing bone-growth potential, but COX-associated inflammation appears to be necessary for in vivo bone growth.

Topics & Keywords

Inflammatory mediators and NSAID effects Oral microbiology and periodontitis research Peptidase Inhibition and Analysis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Periodontology

Volume 76, Issue 11, pp. 1861-1870

DOI: 10.1902/jop.2005.76.11.1861

Field-Weighted Citation Impact: 3.21