The Brain-Derived Neurotrophic Factor val66met Polymorphism and Variation in Human Cortical Morphology

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Authors

Lukas Pezawas · National Institute of Mental Health

Beth A. Verchinski · National Institutes of Health

Venkata S. Mattay · National Institutes of Health

Joseph H. Callicott · National Institutes of Health

Bhaskar Kolachana · National Institutes of Health

Richard E. Straub · National Institutes of Health

Michael Egan

Abstract

A variation in the BDNF gene (val66met) affects the function of BDNF in neurons, predicts variation in human memory, and is associated with several neurological and psychiatric disorders. Here, we show that, in magnetic resonance imaging scans of a large sample of normal individuals, this polymorphism affects the anatomy of the hippocampus and prefrontal cortex, identifying a genetic mechanism of variation in brain morphology related to learning and memory.

Topics & Keywords

Nerve injury and regeneration Nuclear Receptors and Signaling Autism Spectrum Disorder Research

Publication Details

Published in: Journal of Neuroscience

Volume 24, Issue 45, pp. 10099-10102

DOI: 10.1523/jneurosci.2680-04.2004

Field-Weighted Citation Impact: 10.43

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The Brain-Derived Neurotrophic Factor val66met Polymorphism and Variation in Human Cortical Morphology

Authors

Abstract

Topics & Keywords

Publication Details