Oligosaccharide Synthesis on a Fluorous Support

200393 citationsJournal Article

Authors

Tsuyoshi Miura · Noguchi Institute

Kohtaro Goto · Noguchi Institute

Daisuke Hosaka · Noguchi Institute

Toshiyuki Inazu · Noguchi Institute

Abstract

The fluorous support Hfb (see picture) enabled high-yielding oligosaccharide syntheses in which the synthetic intermediates could be purified by simple fluorous–organic solvent extraction, and the reactions could be monitored spectroscopically and by TLC. Hfb was readily attached to the anomeric hydroxy group of a carbohydrate. The fluorous support could be removed in high yield, and was recyclable.

Topics & Keywords

Carbohydrate Chemistry and Synthesis Glycosylation and Glycoproteins Research Chemical Synthesis and Analysis

Publication Details

Published in: Angewandte Chemie International Edition

Volume 42, Issue 18, pp. 2047-2051

DOI: 10.1002/anie.200250531

Field-Weighted Citation Impact: 8.95

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Oligosaccharide Synthesis on a Fluorous Support

Authors

Abstract

Topics & Keywords

Publication Details