Inhibition of Mitochondrial Function by Efavirenz Increases Lipid Content in Hepatic Cells

2010159 citationsJournal Article

Authors

Ana Blas‐García · Universitat de València

Nadezda Apostolova · Universitat de València

Daniel Ballesteros · Universitat de València

Daniel Monleón · Hospital Clínico Universitario de Valencia

José Manuel Morales · Universitat de València

Milagros Rocha · Universitat de València

Víctor M. Víctor

Abstract

Clinical concentrations of EFV induce bioenergetic stress in hepatic cells by acutely inhibiting mitochondrial function. This new mechanism of mitochondrial interference leads to an accumulation of lipids in the cytoplasm that is mediated by activation of AMPK.

Topics & Keywords

HIV/AIDS drug development and treatment HIV-related health complications and treatments HIV Research and Treatment

UN Sustainable Development Goals

Affordable and clean energy

Publication Details

Published in: Hepatology

Volume 52, Issue 1, pp. 115-125

DOI: 10.1002/hep.23647

Field-Weighted Citation Impact: 4.59