A Randomized, Double-Blind Comparison of the NK1 Antagonist, Aprepitant, Versus Ondansetron for the Prevention of Postoperative Nausea and Vomiting

2007192 citationsJournal Article

Authors

Tong J. Gan · Duke Medical Center

Christian C. Apfel · University of California, San Francisco

Anthony L. Kovac · University of Kansas

Beverly K. Philip · Brigham and Women's Hospital

Neil Singla · Huntington Hospital

Harold S. Minkowitz · Memorial Hermann Memorial City Medical Center

Ashraf S. Habib

Abstract

Aprepitant was superior to ondansetron for prevention of vomiting in the first 24 and 48 h, but no significant differences were observed between aprepitant and ondansetron for nausea control, use of rescue, or complete response.

Topics & Keywords

Nausea and vomiting management Anesthesia and Pain Management Anesthesia and Sedative Agents

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Anesthesia & Analgesia

Volume 104, Issue 5, pp. 1082-1089

DOI: 10.1213/01.ane.0000263277.35140.a3

Field-Weighted Citation Impact: 14.86