Aging: ROS or TOR

2008370 citationsReviewhybrid Open Access

Authors

Mikhail V. Blagosklonny · Albany Research Institute

Abstract

It is widely believed that aging is caused by the accumulation of random molecular damage due to reactive oxygen species (ROS). Here I discuss evidence for and against the ROS theory. Remarkably, even supporting evidence has an alternative explanation, consistent with the model that aging is driven by the TOR (target of rapamycin) signaling pathway.

Topics & Keywords

Genetics, Aging, and Longevity in Model Organisms

UN Sustainable Development Goals

Life in Land

Publication Details

Published in: Cell Cycle

Volume 7, Issue 21, pp. 3344-3354

DOI: 10.4161/cc.7.21.6965

Field-Weighted Citation Impact: 7.52