New Synthetic Thrombin Inhibitors: Molecular Design and Experimental Verification

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Authors

Elena I. Sinauridze · National Research Center for Hematology Russian Academy of Medical Sciences

A. N. Romanov · Lomonosov Moscow State University

И. В. Грибкова · Center for Theoretical Problems of Physicochemical Pharmacology

О. А. Кондакова · Lomonosov Moscow State University

Stepan S. Surov · Center for Theoretical Problems of Physicochemical Pharmacology

Aleksander S. Gorbatenko · Federal State Institution Hematology Research Center

Abstract

The high efficacy, stability and low acute toxicity reveal that the inhibitors that were developed may be promising for potential medical applications.

Topics & Keywords

Chemical synthesis and pharmacological studies Computational Drug Discovery Methods Synthesis and biological activity

UN Sustainable Development Goals

Affordable and clean energy

Publication Details

Published in: PLoS ONE

Volume 6, Issue 5, pp. e19969-e19969

DOI: 10.1371/journal.pone.0019969

Field-Weighted Citation Impact: 2.81