Filarial Lymphedema Is Characterized by Antigen-Specific Th1 and Th17 Proinflammatory Responses and a Lack of Regulatory T Cells

2009133 citationsJournal Articlegold Open Access

Authors

Subash Babu · Science Applications International Corporation (United States)

Sajid Q. Bhat · International Centers for Excellence in Research

Nathella Pavan Kumar · International Centers for Excellence in Research

Angelo B. Lipira · International Centers for Excellence in Research

Sanath Kumar · International Centers for Excellence in Research

C. Karthik · International Centers for Excellence in Research

Abstract

Our findings implicate increased Th1/Th17 responses and decreased regulatory T cells as well as regulation of Toll- and Nod-like receptors in pathogenesis of filarial lymphedema.

Topics & Keywords

Parasitic Diseases Research and Treatment Lymphatic System and Diseases Parasites and Host Interactions

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS neglected tropical diseases

Volume 3, Issue 4, pp. e420-e420

DOI: 10.1371/journal.pntd.0000420

Field-Weighted Citation Impact: 4.13