Desflurane-induced Preconditioning Alters Calcium-induced Mitochondrial Permeability Transition

200497 citationsJournal Articlebronze Open Access

Authors

Vincent Piriou

Pascal Chiari

Odile Gateau-Roesch · Scientific Research Institute of Biochemistry

Laurent Argaud

Danina Muntean

Delphine Salles

Joseph Loufouat · National Postdoctoral Association

Pierre‐Yves Gueugniaud

Jean‐Jacques Lehot

Michel Ovize

Abstract

Like ischemic preconditioning, desflurane improved the resistance of the transition pore to calcium-induced opening. This effect was inhibited by 5-HD, suggesting a link between mitochondrial adenosine triphosphate-sensitive potassium and MPT.

Topics & Keywords

Cardiac Ischemia and Reperfusion Anesthesia and Neurotoxicity Research Cardiac Arrest and Resuscitation

UN Sustainable Development Goals

Life below waterClean water and sanitation

Publication Details

Published in: Anesthesiology

Volume 100, Issue 3, pp. 581-588

DOI: 10.1097/00000542-200403000-00018

Field-Weighted Citation Impact: 5.62