HSV-1 DNA in Tears and Saliva of Normal Adults

2004256 citationsJournal Articlegreen Open Access

Authors

Herbert E. Kaufman · Eye Center

Ann M. Azcuy · Eye Center

Emily D. Varnell · Eye Center

Gregory D. Sloop

Hilary W. Thompson · Eye Center

James M. Hill · Czech Academy of Sciences, Institute of Microbiology

Abstract

The percentage of asymptomatic subjects who intermittently shed HSV-1 DNA in tears or saliva was higher than the percentage of subjects with positive ELISA or neutralization antibodies to HSV. Because most HSV transmission occurs during asymptomatic shedding, further knowledge of the prevalence of HSV-1 DNA in tears and saliva is warranted to control its spread. Shedding is simple to study, and its suppression may be an efficient way to evaluate new antivirals in humans.

Topics & Keywords

Herpesvirus Infections and Treatments Cytomegalovirus and herpesvirus research Poxvirus research and outbreaks

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Investigative Ophthalmology & Visual Science

Volume 46, Issue 1, pp. 241-241

DOI: 10.1167/iovs.04-0614

Field-Weighted Citation Impact: 4.25