FRUCTOSE AND CITRIC ACID ASSAY IN THE SECRETIONS OF THE ACCESSORY GLANDS OF REPRODUCTION AS INDICATOR TESTS OF MALE SEX HORMONE ACTIVITY

It is a well-established fact that the weight, size, histological appearance and secretory functions of certain accessory organs of reproduction, such as the seminal vesicle and the prostate, are strictly dependent on, and closely regulated by, the internal secretion of the testes; furthermore, that the typical retrogressive changes which occur in the accessory glands after removal of testes can be counteracted by injections of the testicular hormone, thus serving as 'indicator tests' for the male sex hormone [Deanesly & Parkes, 1933; Korenchevsky, Dennison & Brovsin, 1936; Moore & Gallagher, 1929, 1930; Moore, 1935, 1937, 1947; Price, 1936, 1947; Zuckerman & Parkes, 1938]. Recently, a chemical test was added to these biological reactions in the form of the so-called 'fructose test'. This test was based upon the finding that the activity of testicular hormone in the male is reflected in the capacity of the accessory organs to produce and secrete fructose,