Can we accurately report PTEN status in advanced colorectal cancer?

201411 citationsJournal Articlegold Open Access

Authors

Christopher Hocking · Queen Elizabeth Hospital

Jennifer E. Hardingham · Queen Elizabeth Hospital

Vy Broadbridge · Queen Elizabeth Hospital

Joe Wrin · Basil Hetzel Institute

Amanda Townsend · Queen Elizabeth Hospital

Niall C. Tebbutt · Austin Health

John E. Cooper ·

Abstract

Assessment PTEN loss in colorectal cancer is limited by the inter-observer variability of IHC, and discordance of CNV with loss of protein expression. An understanding of the genetic mechanisms of PTEN loss and implementation of improved and standardized methodologies of PTEN assessment are required to clarify the role of PTEN as a biomarker in colorectal cancer.

Topics & Keywords

Colorectal Cancer Treatments and Studies PI3K/AKT/mTOR signaling in cancer Gastric Cancer Management and Outcomes

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: BMC Cancer

Volume 14, Issue 1, pp. 128-128

DOI: 10.1186/1471-2407-14-128

Field-Weighted Citation Impact: 0.89