Modulation of 11β-Hydroxysteroid Dehydrogenase (11βHSD) Activity Biomarkers and Pharmacokinetics of PF-00915275, a Selective 11βHSD1 Inhibitor

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Authors

Rachel Courtney · Pfizer (United States)

Paul M. Stewart · University of Birmingham

Melvin Toh · Pfizer (United States)

Marie-Noella Ndongo · Pfizer (Belgium)

Roberto A. Calle · Pfizer (United States)

Boaz Hirshberg · Pfizer (United States)

Abstract

PF-00915275 was safe at all doses tested. The results of the prednisolone generation test and the urinary metabolite ratios confirm that PF-00915275 is a selective 11betaHSD1 inhibitor.

Topics & Keywords

Hormonal Regulation and Hypertension Adrenal Hormones and Disorders Apelin-related biomedical research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The Journal of Clinical Endocrinology & Metabolism

Volume 93, Issue 2, pp. 550-556

DOI: 10.1210/jc.2007-1912

Field-Weighted Citation Impact: 3.66