High-Resolution Peripheral Quantitative Computed Tomographic Imaging of Cortical and Trabecular Bone Microarchitecture in Patients with Type 2 Diabetes Mellitus

2010455 citationsJournal Articlebronze Open Access

Authors

Andrew J. Burghardt · University of California, San Francisco

Ahi Sema Issever · University of California, San Francisco

Ann V. Schwartz · University of California, San Francisco

Kevin A. Davis · University of California, San Francisco

Umesh Masharani

Sharmila Majumdar · University of California, San Francisco

Thomas M. Link · University of California, San Francisco

Abstract

The results of this pilot investigation provide a potential explanation for the inability of standard BMD measures to explain the elevated fracture incidence in patients with T2DM. The findings suggest that T2DM may be associated with impaired resistance to bending loads due to inefficient redistribution of bone mass, characterized by loss of intracortical bone offset by an elevation in trabecular bone density.

Topics & Keywords

Medical Imaging Techniques and Applications Bone health and osteoporosis research Bone and Joint Diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The Journal of Clinical Endocrinology & Metabolism

Volume 95, Issue 11, pp. 5045-5055

DOI: 10.1210/jc.2010-0226

Field-Weighted Citation Impact: 14.93