Type 2 Iodothyronine Deiodinase in Skeletal Muscle: Effects of Hypothyroidism and Fasting

200953 citationsJournal Article

Authors

Karen A. Heemstra · Leiden University Medical Center

Maarten R. Soeters · University of Amsterdam

Eric Fliers · University of Amsterdam

Mireille J. Serlie · Academic Medical Center

Jacobus Burggraaf · Centre for Human Drug Research

Martijn B. van Doorn · Centre for Human Drug Research

Agatha A. van der Klaauw

Abstract

Human skeletal muscle D2 mRNA expression is modulated by fasting and insulin, but not by hypothyroidism. The lack of a clear effect of D2 mRNA modulation on the observed low D2 activities questions the physiological relevance of D2 activity in human skeletal muscle.

Topics & Keywords

Thyroid Disorders and Treatments Thyroid Cancer Diagnosis and Treatment Growth Hormone and Insulin-like Growth Factors

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The Journal of Clinical Endocrinology & Metabolism

Volume 94, Issue 6, pp. 2144-2150

DOI: 10.1210/jc.2008-2520

Field-Weighted Citation Impact: 3.31