The CAG repeat polymorphism in the androgen receptor gene affects bone density and bone metabolism in healthy males

2001107 citationsJournal Article

Authors

Michael Zitzmann · Institute of Reproductive Medicine

Maik Brune · Institute of Reproductive Medicine

Britta Kornmann · Institute of Reproductive Medicine

Jörg Gromoll · Institute of Reproductive Medicine

Ralf Junker · Japan Arteriosclerosis Prevention Fund

Eberhard Nieschlag · Institute of Reproductive Medicine

Abstract

A high number of CAG repeats within the androgen receptor gene attenuates testosterone effects on bone density and bone metabolism. This seems to be associated with accelerated age-dependent bone loss.

Topics & Keywords

Sexual Differentiation and Disorders Hormonal and reproductive studies Growth Hormone and Insulin-like Growth Factors

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Endocrinology

Volume 55, Issue 5, pp. 649-657

DOI: 10.1046/j.1365-2265.2001.01391.x

Field-Weighted Citation Impact: 3.27