High-Density Lipoprotein Restores Endothelial Function in Hypercholesterolemic Men

2002439 citationsJournal Article

Authors

Lukas E. Spieker · Swiss Red Cross

Isabella Sudano · Swiss Red Cross

David Hürlimann · Swiss Red Cross

P. Lerch · Swiss Red Cross

Markus Lang · Swiss Red Cross

Christian Binggeli · Swiss Red Cross

Roberto Corti · Swiss Red Cross

Abstract

In hypercholesterolemic patients, intravenous rHDL infusion rapidly normalizes endothelium-dependent vasodilation by increasing NO bioavailability. This may in part explain the protective effect of HDL from coronary heart disease and illustrates the potential therapeutic benefit of increasing HDL in patients at risk from atherosclerosis.

Topics & Keywords

Antioxidant Activity and Oxidative Stress Blood Pressure and Hypertension Studies Cardiovascular Health and Disease Prevention

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 105, Issue 12, pp. 1399-1402

DOI: 10.1161/01.cir.0000013424.28206.8f

Field-Weighted Citation Impact: 12.42