A Novel Substrate-Based HIV-1 Protease Inhibitor Drug Resistance Mechanism

2007167 citationsJournal Articlegold Open Access

Authors

Monique Nijhuis · University Medical Center Utrecht

Noortje M. van Maarseveen · University Medical Center Utrecht

Stéphane Lastère · Hôpital Bichat-Claude-Bernard

P Schipper · University Medical Center Utrecht

Eoin Coakley

Bärbel Glass · Heidelberg University

Mirka Rovenska · Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry

Abstract

HIV can use an alternative mechanism to become resistant to PI by changing the substrate instead of the protease. Further studies are required to determine to what extent cleavage site mutations may explain virological failure during PI therapy.

Topics & Keywords

HIV/AIDS drug development and treatment HIV Research and Treatment HIV/AIDS Research and Interventions

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS Medicine

Volume 4, Issue 1, pp. e36-e36

DOI: 10.1371/journal.pmed.0040036

Field-Weighted Citation Impact: 10.16