<scp>EGF</scp> signalling pathway regulates colon cancer stem cell proliferation and apoptosis

201283 citationsJournal Articlebronze Open Access

Authors

Yun Feng · Ruijin Hospital

Xin Dai · Ruijin Hospital

X. Li · Ruijin Hospital

Hai Wang · Shanghai Jiao Tong University

J. Liu · Shanghai Jiao Tong University

J-P. Zhang · Shanghai Jiao Tong University

Yongrui Du · Shanghai Jiao Tong University

Abstract

This study indicates that EGF signalling was essential for formation and maintenance of colon CSCs. Inhibition of the EGF signalling pathway may provide a useful strategy for treatment of colon cancer.

Topics & Keywords

Cancer Cells and Metastasis Cancer Research and Treatments Cancer, Hypoxia, and Metabolism

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cell Proliferation

Volume 45, Issue 5, pp. 413-419

DOI: 10.1111/j.1365-2184.2012.00837.x

Field-Weighted Citation Impact: 4.84