Optimization of Cardiac Resynchronization Devices Using Acoustic Cardiography: A Comparison to Echocardiography

Optimization of pacemaker settings for cardiac resynchronization therapy (CRT) remains challenging and problematic. Several noninvasive methods are offered to customize the programmed parameters for individual patients, but so far only echocardiographic imaging has established itself as an accepted method. The authors examined the value of acoustic cardiography as a fast and more cost-efficient alternative to established echocardiographic imaging techniques for the optimization of CRT devices. The atrioventricular delay in 22 subjects with implanted CRT devices was independently optimized using echocardiography (Doppler transmitral flow) as well as acoustic cardiography, and the recommended settings from each method were later compared. Doppler echocardiography and acoustic cardiography recommendations matched within a mean value +/- SD of 17+/-16 milliseconds and gave a correlation coefficient of r=0.90 (p<0.001). In 17 of the 22 cases (77.3%), the difference between echocardiographic and acoustic cardiogram CRT optimization results was <or=20 milliseconds. Furthermore, the echocardiographic transmitral flow pattern was not significantly different for the setting independently chosen by the echocardiographic expert and the acoustic cardiographer for the cases with a difference of >20 milliseconds (22.7%). In addition, it took less time for the acoustic cardiogram to collect sufficient information to make a recommendation, and it was found that the acoustic cardiogram data trend is easier to interpret.