Apolipoprotein E Genotype and the Diagnostic Accuracy of Cerebrospinal Fluid Biomarkers for Alzheimer Disease

2014107 citationsJournal Articlebronze Open Access

Authors

Ronald Lautner · University of Gothenburg

Sebastian Palmqvist · Skåne University Hospital

Niklas Mattsson · University of Gothenburg

Ulf Andréasson · University of Gothenburg

Anders Wallin · University of Gothenburg

Erik Pålsson · University of Gothenburg

Joel Jakobsson ·

Abstract

Cerebrospinal fluid levels of Aβ42 are strongly associated with the diagnosis of AD and cortical Aβ accumulation independent of APOE genotype. The clinical cutoff for CSF levels of Aβ42 should be the same for all APOE genotypes.

Topics & Keywords

Alzheimer's disease research and treatments Dementia and Cognitive Impairment Research Amyloidosis: Diagnosis, Treatment, Outcomes

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JAMA Psychiatry

Volume 71, Issue 10, pp. 1183-1183

DOI: 10.1001/jamapsychiatry.2014.1060

Field-Weighted Citation Impact: 6.93