Transplantation of Umbilical-Cord Blood in Babies with Infantile Krabbe's Disease

2005708 citationsJournal Articlebronze Open Access

Authors

Maria L. Escolar · University of North Carolina at Chapel Hill

Michele D. Poe · University of North Carolina at Chapel Hill

David A. Wenger · Jefferson College

Daniel Pietryga

Donna A. Wall · CHRISTUS Transplant Institute

Abstract

Transplantation of umbilical-cord blood from unrelated donors in newborns with infantile Krabbe's disease favorably altered the natural history of the disease. Transplantation in babies after symptoms had developed did not result in substantive neurologic improvement.

Topics & Keywords

Lysosomal Storage Disorders Research Family and Disability Support Research Spinal Dysraphism and Malformations

UN Sustainable Development Goals

Quality Education

Publication Details

Published in: New England Journal of Medicine

Volume 352, Issue 20, pp. 2069-2081

DOI: 10.1056/nejmoa042604

Field-Weighted Citation Impact: 23.34