Systematic Analysis of Immune Infiltrates in High-Grade Serous Ovarian Cancer Reveals CD20, FoxP3 and TIA-1 as Positive Prognostic Factors

2009430 citationsJournal Articlegold Open Access

Authors

Katy Milne · BC Cancer Agency

Martin Köbel · Vancouver General Hospital

Steven E. Kalloger · Vancouver General Hospital

Rebecca Barnes · BC Cancer Agency

Dongxia Gao · University of British Columbia

C. Blake Gilks · Vancouver General Hospital

Peter H. Watson ·

Abstract

Host immune responses to EOC vary widely according to histological subtype and the extent of residual disease. TIA-1, FoxP3 and CD20 emerge as new positive prognostic factors in high-grade serous EOC from optimally debulked patients.

Topics & Keywords

Immune Cell Function and Interaction Cancer Immunotherapy and Biomarkers Immune cells in cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 4, Issue 7, pp. e6412-e6412

DOI: 10.1371/journal.pone.0006412

Field-Weighted Citation Impact: 5.33