Onset of Mechanical Ventilation Is Associated With Rapid Activation of Circulating Phagocytes in Preterm Infants

200660 citationsJournal Article

Authors

Riikka Turunen · State Institution "Institute for Children and Adolescents Health Care at the National Academy of Medical Sciences of Ukraine"

Irmeli Nupponen · State Institution "Institute for Children and Adolescents Health Care at the National Academy of Medical Sciences of Ukraine"

Sanna Siitonen · University of Helsinki

Heikki Repo · Helsinki University Hospital

Sture Andersson · State Institution "Institute for Children and Adolescents Health Care at the National Academy of Medical Sciences of Ukraine"

Abstract

In preterm infants with RDS, significant activation of circulating phagocytes occurs within 1 to 3 hours of the onset of mechanical ventilation, independent of surfactant administration, which indicates that mechanical ventilation may be the inducer of this systemic inflammatory response.

Topics & Keywords

Neonatal Respiratory Health Research Respiratory Support and Mechanisms Neuroscience of respiration and sleep

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PEDIATRICS

Volume 117, Issue 2, pp. 448-454

DOI: 10.1542/peds.2005-0123

Field-Weighted Citation Impact: 4.87