Molecular correlates of platinum response in human high‐grade serous ovarian cancer patient‐derived xenografts

2014140 citationsJournal Articlebronze Open Access

Authors

Monique Topp · Walter and Eliza Hall Institute of Medical Research

Lynne Hartley · Walter and Eliza Hall Institute of Medical Research

Michele Cook · Walter and Eliza Hall Institute of Medical Research

Valerie Heong · Royal Women's Hospital

Emma Boehm · Walter and Eliza Hall Institute of Medical Research

Lauren McShane · Walter and Eliza Hall Institute of Medical Research

Jan Pyman

Abstract

Because PDX platinum response reflected clinical outcome, these annotated PDXs will provide a unique model system for preclinical testing of novel therapies for HG-SOC.

Topics & Keywords

CRISPR and Genetic Engineering Cancer Genomics and Diagnostics DNA Repair Mechanisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Molecular Oncology

Volume 8, Issue 3, pp. 656-668

DOI: 10.1016/j.molonc.2014.01.008

Field-Weighted Citation Impact: 6.56