Relationship Between the<i>HLA-B*1502</i>Allele and Carbamazepine-Induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

2013250 citationsReview

Authors

Wimonchat Tangamornsuksan · Naresuan University

Nathorn Chaiyakunapruk · University of Queensland

Manupat Lohitnavy · Phitsanulok University

Wichittra Tassaneeyakul · Khon Kaen University

Abstract

We found a strong relationship between the HLA-B*1502 allele and carbamazepine-induced SJS and TEN in Han-Chinese, Thai, and Malaysian populations. HLA-B*1502 screening in patients requiring carbamazepine therapy is warranted.

Topics & Keywords

Drug-Induced Adverse Reactions Autoimmune Bullous Skin Diseases Urticaria and Related Conditions

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JAMA Dermatology

Volume 149, Issue 9, pp. 1025-1025

DOI: 10.1001/jamadermatol.2013.4114

Field-Weighted Citation Impact: 13.65