Hematotox1city of inhaled benzene to Sprague‐Dawley rats and AKR mice at 300 ppm

197869 citationsJournal Article

Authors

Carroll A. Synder · Cardiovascular Institute of the South

Bernard D. Goldstein · New York University

Arthur R. Sellakumar · New York University

Sandra R. Wolman · New York University

Isabel Bromberg · New York University

M Erlichman · New York University

Sidney Laskin ·

Abstract

Sprague-Dawley rats and AKR/J mice were exposed to 300 ppm benzene vapor for 6 h/d, 5 d/wk, for life. Rats exhibited lymphocytopenia, mild anemia, and moderately decreased survival. Mice showed severe lymphocytopenia and anemia accompanied by granulocytosis and reticulocytosis. Treated mice also showed significantly decreased survival and weight gain. No indications of a leukemic or preleukemic response were observed in either species.

Topics & Keywords

Immunotoxicology and immune responses Carcinogens and Genotoxicity Assessment Animal testing and alternatives

Publication Details

Published in: Journal of Toxicology and Environmental Health

Volume 4, Issue 4, pp. 605-618

DOI: 10.1080/15287397809529683

Field-Weighted Citation Impact: 1.63

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Hematotox1city of inhaled benzene to Sprague‐Dawley rats and AKR mice at 300 ppm

Authors

Abstract

Topics & Keywords

Publication Details