Erythrocyte Receptors for ( <i>Plasmodium Knowlesi</i> ) Malaria: Duffy Blood Group Determinants

1975617 citationsJournal Article

Authors

Louis H. Miller · National Institute of Allergy and Infectious Diseases

Steven J. Mason · National Institute of Allergy and Infectious Diseases

James A. Dvorak · National Institute of Allergy and Infectious Diseases

Mary H. McGinniss · National Institutes of Health Clinical Center

Ivan Rothman · National Institutes of Health Clinical Center

Abstract

Duffy blood group negative human erythrocytes (FyFy) are resistant to infection by Plasmodium knowlesi, a simian malaria that infects Duffy positive human erythrocytes. The P. knowlesi resistance factor, Duffy negative erythrocytes, occurs in high frequency in West Africa, where the people are resistant to vivax malaria. This suggests that Duffy blood group determinants (Fya or Fyb) may be erythrocyte receptors for P. vivax.

Topics & Keywords

Malaria Research and Control

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Science

Volume 189, Issue 4202, pp. 561-563

DOI: 10.1126/science.1145213

Field-Weighted Citation Impact: 32.82