Cannabidiol displays unexpectedly high potency as an antagonist of CB1and CB2receptor agonistsin vitro

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Authors

Adèle Thomas · University of Aberdeen

Gemma L. Baillie · University of Aberdeen

Angela M. Phillips · University of Aberdeen

Raj K. Razdan · Organix (United States)

Ruth A. Ross · University of Aberdeen

Roger G. Pertwee · University of Aberdeen

Abstract

This study has provided the first evidence that cannabidiol can display CB2 receptor inverse agonism, an action that appears to be responsible for its antagonism of CP55940 at the human CB2 receptor. The ability of cannabidiol to behave as a CB2 receptor inverse agonist may contribute to its documented anti-inflammatory properties.

Topics & Keywords

Cannabis and Cannabinoid Research Diet, Metabolism, and Disease Neurotransmitter Receptor Influence on Behavior

Publication Details

Published in: British Journal of Pharmacology

Volume 150, Issue 5, pp. 613-623

DOI: 10.1038/sj.bjp.0707133

Field-Weighted Citation Impact: 18.35

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Cannabidiol displays unexpectedly high potency as an antagonist of CB<sub>1</sub>and CB<sub>2</sub>receptor agonists<i>in vitro</i>

Authors

Abstract

Topics & Keywords

Publication Details