Optimizing bioreactors by extremum seeking

The optimization of the operation of biological reactors is an interesting non-linear problem whose solution offers potential economic benefit. We apply a peak seeking method to approach the maximum biomass production rate in a continuous stirred tank bioreactor. Two models, Monod and Haldane, are investigated and it is shown by simulation that the peak seeking scheme achieves optimization for both cases. A stabilizing feedback controller with a washout filter is designed to extend the operating range for the Haldane model. Copyright © 1999 John Wiley & Sons, Ltd.