Ceramide-CD300f binding suppresses experimental colitis by inhibiting ATP-mediated mast cell activation

201564 citationsJournal Articlehybrid Open Access

Authors

Toshihiro Matsukawa · Hokkaido University

Kumi Izawa · Juntendo University

Masamichi Isobe · The University of Tokyo

Mariko Takahashi · The University of Tokyo

Akie Maehara · The University of Tokyo

Yoshinori Yamanishi · The University of Tokyo

Ayako Kaitani ·

Abstract

LMIR3-deficient colonic mast cells were pivotal in the exacerbation of DSS-induced colitis in LMIR3(-/-) mice. Ceramide liposomes attenuated DSS-induced colitis by inhibiting ATP-mediated activation of colonic mast cells through ceraimide-LMIR3 binding.

Topics & Keywords

Immune Cell Function and Interaction Inflammation biomarkers and pathways Sphingolipid Metabolism and Signaling

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Gut

Volume 65, Issue 5, pp. 777-787

DOI: 10.1136/gutjnl-2014-308900

Field-Weighted Citation Impact: 3.46