Immunocyte Ca <sup>2+</sup> Influx System Mediated by LTRPC2

2001440 citationsJournal Article

Authors

Yorikata Sano · Drug Discovery Laboratory (Norway)

Kohei Inamura · Drug Discovery Laboratory (Norway)

Akira Miyake · Drug Discovery Laboratory (Norway)

Shinobu Mochizuki · Drug Discovery Laboratory (Norway)

Hiromichi Yokoi · Drug Discovery Laboratory (Norway)

Hitoshi Matsushime · Drug Discovery Laboratory (Norway)

Kiyoshi Furuichi

Abstract

We characterized an activation mechanism of the human LTRPC2 protein, a member of the transient receptor potential family of ion channels, and demonstrated that LTRPC2 mediates Ca2+ influx into immunocytes. Intracellular pyrimidine nucleotides, adenosine 5'-diphosphoribose (ADPR), and nicotinamide adenine dinucleotide (NAD), directly activated LTRPC2, which functioned as a Ca2+-permeable nonselective cation channel and enabled Ca2+ influx into cells. This activation was suppressed by intracellular adenosine triphosphate. These results reveal that ADPR and NAD act as intracellular messengers and may have an important role in Ca2+ influx by activating LTRPC2 in immunocytes.

Topics & Keywords

Calcium signaling and nucleotide metabolism Ion channel regulation and function Ion Channels and Receptors

Publication Details

Published in: Science

Volume 293, Issue 5533, pp. 1327-1330

DOI: 10.1126/science.1062473

Field-Weighted Citation Impact: 10.04

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Immunocyte Ca <sup>2+</sup> Influx System Mediated by LTRPC2

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Abstract

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Publication Details