Is overexpression of HER-2 a predictor of prognosis in colorectal cancer?

2009368 citationsJournal Articlegold Open Access

Authors

Dara O. Kavanagh · Mayo General Hospital

Gillian Chambers · Mayo General Hospital

Liam O' Grady · Mayo General Hospital

Kevin M. Barry · Mayo General Hospital

R. Waldron · Mayo General Hospital

Fadel Bennani · Mayo General Hospital

Paul W. Eustace ·

Abstract

HER-2 protein is over expressed in 11% of colorectal cancer patients. The gene encoding HER-2 is amplified in 3% of cases. Overexpression of HER-2 is not a predictor of outcome. However, patients who over express HER-2 may respond to Herceptin therapy.

Topics & Keywords

HER2/EGFR in Cancer Research Colorectal Cancer Treatments and Studies Gastric Cancer Management and Outcomes

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: BMC Cancer

Volume 9, Issue 1, pp. 1-1

DOI: 10.1186/1471-2407-9-1

Field-Weighted Citation Impact: 7.39