Size Separation of Circulatory DNA in Maternal Plasma Permits Ready Detection of Fetal DNA Polymorphisms

2004246 citationsJournal Articlebronze Open Access

Authors

Ying Li · University of Basel

Bernhard Zimmermann · University of Basel

Corinne Rusterholz · University of Basel

Anjeung Kang · University of Basel

Wolfgang Holzgreve · University of Basel

Sinuhe Hahn · University of Basel

Abstract

Circulatory fetal DNA can be enriched by size selection of fragment sizes less than approximately 0.3 kb. Such selection permits easier analysis of both paternally and maternally inherited DNA polymorphisms.

Topics & Keywords

Prenatal Screening and Diagnostics Fetal and Pediatric Neurological Disorders Parvovirus B19 Infection Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Chemistry

Volume 50, Issue 6, pp. 1002-1011

DOI: 10.1373/clinchem.2003.029835

Field-Weighted Citation Impact: 19.59