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Article1 November 1964Risk Factors in Coronary Heart DiseaseThe Framingham StudyWILLIAM B. KANNEL, M.D., F.A.C.P., THOMAS R. DAWBER, M.D., F.A.C.P., GARY D. FRIEDMAN, M.D., WILLIAM E. GLENNON, M.S., PATRICIA M. MCNAMARAWILLIAM B. KANNEL, M.D., F.A.C.P.Search for more papers by this author, THOMAS R. DAWBER, M.D., F.A.C.P.Search for more papers by this author, GARY D. FRIEDMAN, M.D.Search for more papers by this author, WILLIAM E. GLENNON, M.S.Search for more papers by this author, PATRICIA M. MCNAMARASearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-5-888 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAt Framingham, Massachusetts, the National Heart Institute has been following 5,127 men and women aged 30 to 60 years in a study of factors related to the development of coronary heart disease (CHD) and hypertension. Data for a decade of follow-up studies of this population are available for analysis.From a study of those who have developed disease under observation in comparison to those who have remained free of the disease, factors of risk and susceptible individuals have been identified. The factors associated with excess risk that have been identified are: serum cholesterol level, blood pressure, cigarette smoking, vital capacity,...References1. GORDONMOORESHURTLEFFDAWBER TFEDTR: Some methodologic problems in the long-term study of cardiovascular disease: observations on the Framingham Study. J. Chron. Dis. 10: 186, 1959. CrossrefGoogle Scholar2. KANNELDAWBERKAGANREVOTSKIESTOKES WBTRANJ: Factors of risk in the development of coronary heart disease—six-year follow-up experience: The Framingham Study. Ann. Intern. Med. 55: 33, 1961. LinkGoogle Scholar3. KAHN HA: A method for analyzing longitudinal observations on individuals in the Framingham Heart Study. Proceedings of the Social Statistics Section of the American Statistical Association, 1961. Google Scholar4. DELALLAGOFMAN OFJW: Ultracentrifugal analysis of serum lipoprotein, in Methods of Biochemical Analysis, vol. 1, edited by GLICK, D., Interscience, New York, 1954, pp. 459-478. Google Scholar5. ABELLLEVYBRODIEKENDALL LLBBBBFE: A simplified method for estimation of total cholesterol in serum and demonstration of its specificity. J. Biol. Chem. 195: 357, 1952. CrossrefMedlineGoogle Scholar6. YOUNGBURGYOUNGBURG GEMV: Phosphorus metabolism; system of blood phosphorus analysis. J. Lab. Clin. Med. 16: 158, 1930. Google Scholar7. FISKESUBARROW CHY: The colorimetric determination of phosphorus. J. Biol. Chem. 66: 375, 1925. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Framingham, MassachusettsFrom the Heart Disease Epidemiology Study, Framingham, Mass., and the National Heart Institute, National Institutes of Health, U. S. Public Health Service, Bethesda, Md.Requests for reprints should be addressed to William B. Kannel, M.D., Heart Disease Epidemiology Study, Dept. of Health, Education, and Welfare, 25 Evergreen St., Framingham, Mass. 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KANNEL, M.D., WILLIAM M.D., PATRICIA M. of lipid en la Disease and and of coronary of myocardial and Cardiovascular study of the primary prevention of coronary heart in Atherosclerosis: and Drug Ischemic Heart Disease, and M.D., M. M.D., M.D., J. of the of Heart Disease: by the Framingham IN Type Effects of and abnormalities in patients with coronary artery basis of human Pressure and Risk of Coronary Heart Disease: The Framingham in the and IN Serum Triglyceride and Cholesterol Levels heart disease in of and in Young Patients with Coronary Heart of heart changes in chronic IN Heart Disease: Screening by Familial and Coronary Artery D. in Human Atherosclerosis With Therapeutic M.D., A IN of serum lipids and of lipoprotein in myocardial Lipids in Infarction American M.D., of atherosclerotic in and Atherosclerotic Vascular and Lipid in Patients with Coronary Heart M.D., M.D., J. M.D., of on serum fat in atherosclerotic in the clinical analysis of coronary lipoprotein levels in a New population prevention of coronary heart disease by clinical of coronary A Nutrition and Atherosclerotic in prevention of coronary heart Disease, and of on the of Diagnosis of Heart in with Blood Serum and development of coronary heart disease in relation to of cholesterol in the Study of Coronary Heart Disease in Young of fat in relation to in assessment of the of the in the of cardiovascular to M.D., F.A.C.P., M.D., M.D., Advances in of Coronary Artery Mechanism and Prevention by November heart heart risk and health November PDF
Published in: Annals of Internal Medicine
Volume 61, Issue 5_Part_1, pp. 888-899